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Debate: Stimulant Drugs Cause Increase in Future Drug Abuse

It seems common sense that giving a child a Class II Narcotic Drug, like cocaine, to help get through tough times and to control one's behavior would lead that child to believe they really don't have control of themselves, as this is what is being told to them via the pill.  Is it any surprise then their internal locus of control is dampened?

This study found more drug addiction in children with ADHD who took methylphenidate
compared with children with ADHD who took no drugs (J Learn, Disabil. 1998;31:533-544);

 

Addiction, Volume 101, Issue 5 Page 713  - May 2006, doi:10.1111/j.1360-0443.2006.01408.x

Subjective responses to initial experience with cocaine: an exploration of the incentive–sensitization theory of drug abuse

Nadine M. Lambert1, Marsha McLeod1 & Susan Schenk2

 ABSTRACT

This study investigated the relationship between positive and negative subjective responses at the time of initial cocaine use with adult cocaine dependence and life-time use rates. Psycho-stimulant pre-exposure, regular smoking or stimulant treatment before initiation were examined to explore the incentive sensitization theory of addiction.  A total of 202 adult participants who had tried cocaine on at least one occasion were studied prospectively from childhood into adulthood. The cocaine-initiated group included 89 who met Diagnostic and Statistical Manual version IV (DSM-IV) criteria for attention deficit hyperactive disorder (ADHD) and 113 age-matched controls.

Five childhood and three adulthood interviews provided data on ages of initiation into cocaine and life-time use of cocaine from ages 16–40 years. Correlations of each subjective response and analyses of variance (ANOVAs) of cocaine 'liking' and 'wanting' with DSM-III-R cocaine dependence and life-time use provided support for the validity of the measures. ANOVA provided evidence of the effect of psychostimulant pre-exposure on 'liking' and 'wanting'. Logistic regression modeled the prediction of dependence and life-time use with the independent variables of 'liking' and 'wanting', psychostimulant pre-exposure and participant characteristics.

When cocaine was first tried, 'liking' and 'wanting' were significant predictors of cocaine dependence and life-time use. Mean 'liking' or 'wanting' responses did not differ by participant characteristics. Those who were pre-exposed by regular smoking or stimulant treatment had higher 'liking' and 'wanting' scores; but participants who were pre-exposed by both stimulant treatment and regular smoking reported the lowest liking and the highest wanting responses, consistent with the incentive sensitization theory.  Logistic regression showed that the 'liking' and 'wanting' responses increased significantly the odds of DSM-III-R cocaine dependence and life-time use.  Conclusion  In this sample, subjective 'liking' and 'wanting' measured risk for cocaine abuse.

Now, the other really well paid researchers... Hartsough CS, Lambert NM. Pattern and progression of drug use among hyperactives and controls: a prospective short-term longitudinal study. J Child Psychol Psychiatry 1987 Jul;28(4):543-53, and 

The Barkley et al, Farone & Willens, Biederman et al studies were a direct response to refute her ongoing study. Barkely, Farone and Biederman studies all show that stimulant treatment prevents the development of substance abuse disorder - particularly tobacco and cocaine.

The way they did this is by taking out any kids who develop comorbid CD or ODD. They say they were not true "ADHD" and take them out of the treatment group.

Biederman also had a trick of using controls who were the elder siblings of the ADHD treatment group. In his study the average age of controls was around 17 and the treatment  group around 15 years. The fact the controls were on average two years older, had access to driving etc significantly increase the controls of having access to cocaine and crack bias Biederman's results totally.

 Nadine was one of the old school in the ADHD group going back to the 1970s. She goes way back. She once made a comment to me that Barkley really used to like her work until she found something that he didn't like. She was of the opinion that the others were all in the hands of big pharma. I thought she published her latest findings in EHPP journal a few years ago!

 

Also, "A group of 65 children with ADHD who had never taken medication grew somewhat larger — about three-fourths of an inch and 6 pounds more, on average — than a group of 88 peers who stayed on medication over the three years. Growth rates normalized for the children on medication by the third year, but they had not made up for the earlier slowing in growth.

"...despite (drug) treatment, the children with ADHD showed significantly higher-than-normal rates of delinquency (27.1 percent vs. 7.4 percent) and substance use (17.4 percent vs. 7.8 percent) after three years. Earlier evidence of lower substance use rates among children who had received intensive behavioral therapy had lessened by the third year."  http://www.nimh.nih.gov/press/mtafollowup.cfm

 

 

 

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